Sam De Brouwer

Co-Founder & Chief Executive Officer, XY.AI Labs

Sam De Brouwer is co-founder and CEO of XY.AI Labs, which builds agentic AI for healthcare operations. She co-founded doc.ai, acquired by Sharecare in 2021, and Scanadu, whose first clinical trial ran with the Scripps Translational Science Institute. Her career began in Europe in the 1990s.

Sam De Brouwer speaking on stage, wearing a headset microphone and holding notes
Sam De Brouwer, co-founder and CEO of XY.AI Labs.

Now

2026–present

SIGNALS

Volunteer

Finding Signals Inside Complex Systems.

2025–present

XY.AI Labs

Co-Founder & Chief Executive Officer

Agentic AI for healthcare operations. Board member since July 2023.

2024–present

Claritas Athena Ventures

Senior Advisor

The venture arm of Claritas Capital, Nashville.

2022–present

BetterNight

Board Member

Patient-centric sleep care across physicians, health plans, ACOs and employers.

Previously

2023–2026

TEDAI San Francisco

Co-Founder & Curator

Started and curated TED's AI chapter, with Walter De Brouwer.

2021–2025

Sharecare

Chief Strategy Officer

Joined via Sharecare's acquisition of doc.ai, February 2021.

2019–2020

San Francisco Girls Chorus

Board Member

2018–2019

Stanford University

MMI Rater, MD Admissions

2018–2019

Research to the People (SVAI)

Board of Advisors

Non-profit accelerating AI for biomedicine through collaborative research.

2016–2019

Emmaai

Angel Investor

Neural networks for financial services.

2016–2021

doc.ai

Co-Founder; Chief Operating Officer, then Chief Executive Officer

Federated learning on real-world data for predictive models and personal health insights. COO 2016–2020, CEO 2020–2021. Acquired by Sharecare.

2012–2016

Scanadu

Co-Founder & VP Communications

NASA Ames. FDA 510(k)-cleared smartphone urine test, and early medical-grade wireless vital-signs readers. Its first clinical study, with the Scripps Translational Science Institute, enrolled over 4,000 participants. The company later relaunched as inui Health, which Healthy.io acquired in 2020.

2010–2013

One Laptop Per Child Europe

Advocacy Director

Raised funds to equip two million children.

2009–2015

TEDxBrussels

Director & TED Ambassador

1996–1998

Jobscape

Co-Founder, founding team

One of Europe's first online employment platforms. Acquired by StepStone.

1996–2001

Starlab

Head of Go-To-Market, Brussels HQ

Interdisciplinary research lab.

Work in

Elsewhere