2026–present
SIGNALS
Volunteer
Finding Signals Inside Complex Systems.
Co-Founder & Chief Executive Officer, XY.AI Labs
Sam De Brouwer is co-founder and CEO of XY.AI Labs, which builds agentic AI for healthcare operations. She co-founded doc.ai, acquired by Sharecare in 2021, and Scanadu, whose first clinical trial ran with the Scripps Translational Science Institute. Her career began in Europe in the 1990s.

2026–present
SIGNALS
Volunteer
Finding Signals Inside Complex Systems.
2025–present
Co-Founder & Chief Executive Officer
Agentic AI for healthcare operations. Board member since July 2023.
2024–present
Claritas Athena Ventures
Senior Advisor
The venture arm of Claritas Capital, Nashville.
2022–present
BetterNight
Board Member
Patient-centric sleep care across physicians, health plans, ACOs and employers.
2023–2026
TEDAI San Francisco
Co-Founder & Curator
Started and curated TED's AI chapter, with Walter De Brouwer.
2021–2025
Sharecare
Chief Strategy Officer
Joined via Sharecare's acquisition of doc.ai, February 2021.
2019–2020
San Francisco Girls Chorus
Board Member
2018–2019
Stanford University
MMI Rater, MD Admissions
2018–2019
Research to the People (SVAI)
Board of Advisors
Non-profit accelerating AI for biomedicine through collaborative research.
2016–2019
Emmaai
Angel Investor
Neural networks for financial services.
2016–2021
doc.ai
Co-Founder; Chief Operating Officer, then Chief Executive Officer
Federated learning on real-world data for predictive models and personal health insights. COO 2016–2020, CEO 2020–2021. Acquired by Sharecare.
2012–2016
Scanadu
Co-Founder & VP Communications
NASA Ames. FDA 510(k)-cleared smartphone urine test, and early medical-grade wireless vital-signs readers. Its first clinical study, with the Scripps Translational Science Institute, enrolled over 4,000 participants. The company later relaunched as inui Health, which Healthy.io acquired in 2020.
2010–2013
One Laptop Per Child Europe
Advocacy Director
Raised funds to equip two million children.
2009–2015
TEDxBrussels
Director & TED Ambassador
1996–1998
Jobscape
Co-Founder, founding team
One of Europe's first online employment platforms. Acquired by StepStone.
1996–2001
Starlab
Head of Go-To-Market, Brussels HQ
Interdisciplinary research lab.